課程大綱

課程資訊

課程名稱	高等化學生物學專論二 Discussion in Advanced Chemical Biology (Ⅱ)
開課學期	107-2
授課對象	理學院化學所化學生物學組
授課教師	吳世雄
課號	Chem8036
課程識別碼	223ED1620
班次
學分	3.0
全/半年	半年
必/選修	必修
上課時間	星期五2,3,4(9:10~12:10)
上課地點
備註	本課程以英語授課。TIGP-CB組必修課程。上課教室：化121。限博士班總人數上限：30人
Ceiba 課程網頁	http://ceiba.ntu.edu.tw/1072Chem8036
課程簡介影片
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課程概述	This courses aim to provide students with general knowledge in the synthesis of biomolecules, which is applied either to prepare small molecules to probe target DNA/proteins, or to develop efficient methods to study biological questions. Therefore one half of the time is used to cover the synthesis, while the other half is to talk about their applications.
課程目標	Students who want to take the course need to pass the undergraduate course of organic chemistry (two semester courses with at least 2 hours per week). It is also recommended to have basic concept in biochemistry, at least to be aware of what are the structures of amino acids, nucleic acids and sugars.
課程要求
預期每週課後學習時數
Office Hours
指定閱讀
參考書目
評量方式 (僅供參考)

課程進度

週次	日期	單元主題
第1週	2/22	Antibiotics (particularly for beta-Lactam) and Their Resistance by Dr. Shih-Hsiung Wu
第2週	3/1	228 Holiday
第3週	3/8	Preparation of Conjugate Vaccine against Pathogenic Bacteria by Dr. Shih-Hsiung Wu
第4週	3/15	Natural Products – Classification, Biosynthesis and Drug Discovery by Dr. Hsiao-Ching Lin
第5週	3/22	Natural Products – Classification, Biosynthesis and Drug Discovery by Dr. Hsiao-Ching Lin
第6週	3/29	Anti-Amyloid Peptide Therapy, Peptide Drug and Alzheimer’ s disease (or protein folding and neurodegenerative diseases) by Dr. Rita PY Chen
第7週	4/5	No Class-Observe the Tomb Sweeping Day
第8週	4/12	Natural Products – Classification, Biosynthesis and Drug Discovery by Dr. Hsiao-Ching Lin
第9週	4/19	Anti-Amyloid Peptide Therapy, Peptide Drug and Alzheimer’ s disease (or protein folding and neurodegenerative diseases) by Dr. Rita PY Chen
第10週	4/26	Anti-Amyloid Peptide Therapy, Peptide Drug and Alzheimer’ s disease (or protein folding and neurodegenerative diseases) by Dr. Rita PY Chen
第11週	5/3	Midterm Exam
第12週	5/10	Anti-Virus and Anti-Cancer Drug Discovery by Dr. Po-Huang Liang
第13週	5/17	Anti-Virus and Anti-Cancer Drug Discovery by Dr. Po-Huang Liang
第14週	5/24	Anti-Virus and Anti-Cancer Drug Discovery by Dr. Po-Huang Liang
第15週	5/31	Combinatorial Chemistry-Parallel synthesis & Combinatorial Chemistry-Parallel synthesis & High-Throughput Drug Screening by Dr. Wenshan Li
第16週	6/7	Holiday ( Dragon Boat Festival)
第17週	6/14	Rational Design of Enzyme Inhibitors-Drug design: identification of a pharmacophore and lead optimization Or Specific labeling on biomolecules-Case study by Dr. Wenshan Li
第18週	6/21	Final Exam